Exocyclic DNA Adducts in Mutagenesis and Carcinogenesis

IARC Scientific Publication No. 150

Edited by Singer B, Bartsch H





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The use of exocyclic adducts as biomarkers offers a promising tool in studies of cancer etiology and prevention, particularly for human neoplasias in which the causative factors and mechanisms are still poorly understood. Presentations at an international conference which resulted in this volume comprise a comprehensive treatise on the current state of the art and scientific information on exocyclic DNA adducts. The volume includes sections on ultrasensitive detection methods, formation from exogenous and endogenous sources, DNA repair, physical chemical approaches to structural elucidation, use as biomarkers and their role in mutagenesis and carcinogenesis.