This volume is a compendium of knowledge on physico-chemical properties, methods for synthesis and detection, and the biological relevance of several hundred known DNA adducts that are produced by some 20 classes of carcinogens and mutagens. It represents the combined efforts of leading specialists in the field of DNA adduct formation and its biological significance, who met at the Center for Nutrition and Toxicology of the Karolinska Institute in Huddinge, Sweden, on 18-21 November 1992, and should constitute a useful source of critically evaluated information.