Vitamin A

IARC Handbooks of Cancer Prevention Volume 3



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This third volume of the IARC Handbooks of Cancer Prevention evaluates the cancer preventive potential of vitamin A. The handbook provides a comprehensive review and evaluation of the relevant information in the published scientific literature through April 1998 on the cancer-preventive activity of retinol and retinyl esters. The observed effects of preformed vitamin A on cell and organ culture, on animal models, in dietary observational epidemiological studies, and in human intervention studies are reviewed.

Cover Page, Contents, List of participants, Preamble, General Remarks
Chapter 1. Chemical and physical characteristics of vitamin A
Chapter 2. Occurrence, production, use, analysis and human exposure
Chapter 3. Metabolism, kinetics, tissue distribution and inter- and intra-species variation
Chapter 4. Preventive effects
Chapter 5. Other beneficial effects
Chapter 6. Carcinogenicity
Chapter 7. Other toxic effects
Chapter 8. Summary of data
Chapter 9. Recommendations for future research
Chapter 10. Evaluation
Appendix 1, Appendix 2, Appendix 3, Appendix 4