Some Thyrotropic Agents

IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 79



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This volume evaluates carcinogenicity to humans of 19 chemicals that are carcinogenic to the thyroid follicular-cell epithelium in rodents. These included some so-called 'anti-thyroid' drugs (methimazole, methylthiouracil, propylthiou-racil and thiouracil); some sedatives (doxylamine succinate and phenobarbital); and some other drugs including the systemic antifungal antibiotic griseofulvin, the diuretic spironolactone, and the antibacterial sulfa drugs sulfamethazine and sulfamethoxazole. Other chemicals are or have been used in agriculture as pesticides (amitrole, chlordane/heptachlor, hexachlo-robenzene and toxaphene), in foods and cosmetics (kojic acid), in hair dyes (2,4-diaminoanisole) or as industrial chemicals (N,N'-diethylthiourea, ethylenethiourea and thiourea).