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Re-evaluation of Some Organic Chemicals, Hydrazine and Hydrogen Peroxide (Part 1, Part 2, Part 3)

IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 71

IARC

ISBN-13 (Print Book)

978-92-832-1271-3

ISBN-13 (PDF)

978-92-832-1571-4

Formats

Print Book

PDF

Other languages

No other languages


Provides re-evaluations of the carcinogenic risks to humans posed by exposure to some 121 organic compounds, mostly industrial chemicals, selected from among the 834 agents evaluated in volumes 1-70 of the IARC Monographs series. Chemicals were selected for re-evaluation on the basis of considerable new evidence that might call for a change in the IARC classification of carcinogenic risk. The evaluations are presented in three parts. Part one provides full assessments of all relevant data on experimental carcinogenesis and cancer epidemiology for four chemicals: acrylonitrile, 1,3-butadiene, chloroprene, and dichloromethane. Of these, 1,3-butadiene remained classified as probably carcinogenic to humans, and dichloromethane remained classified as possibly carcinogenic to humans. Acrylonitrile, previously classified as probably carcinogenic to humans, was reclassified as possibly carcinogenic. For chloroprene, previously judged not classifiable, new epidemiological evidence and new bioassays demonstrating carcinogenicity in rats and mice supported classification as possibly carcinogenic to humans. Part two re-evaluates 30 compounds for which new epidemiological or experimental carcinogenicity data were available and for which changes in classification were anticipated. Part three provides brief updates for 76 compounds and groups of compounds for which new evidence was restricted to experimental carcinogenicity data. As no new epidemiological evidence was available, and no reclassification was anticipated, these monographs reproduce the previous summary evaluations and update these with descriptions of new data.

FRONT AND BACK MATTER

  Cover
  Contents and Note to the Reader
  List of Participants
  Preamble
  General Remarks
  Summary of Final Evaluations
  Cumulative Cross Index to IARC Monographs

 

THE MONOGRAPHS

 

Part One: Compounds reviewed in plenary sessions (comprehensive monographs)

Acrylonitrile

1,3-Butadiene [superseded by Volume 97]

Chloroprene

Dichloromethane

 

Part Two: Other compounds reviewed in plenary sessions

 

Acetaldehyde [see also Volume 96]

Aziridine

Benzoyl peroxide

n-Butyl acrylate

γ-Butyrolactone

Caprolactam

Carbon tetrachloride

Catechol

α-chlorinated toluenes and benzoyl chloride

1,2-Dibromo-3-chloropropane

1,2-Dichloroethane

Dimethylcarbamoyl chloride

Dimethylformamide

Dimethyl sulfate

1,4-Dioxane

Epichlorohydrin

1,2-Epoxybutane

Ethylene dibromide (1,2-dibromoethane)

Hydrogen peroxide

Hydroquinone

Methyl bromide

Methyl chloride

Phenol

Polychlorophenols and their sodium salts [see also Volume 117]

1,1,2,2-Tetrachloroethane

Toluene

Toluene diisocyanates

1,1,1-Trichloroethane

Tris(2,3-dibromopropyl) phosphate

Vinyl bromide [superseded by Volume 97]

 

Part Three: Compounds not reviewed in plenary sessions

Part Three A: Extensive new data requiring new summaries

1,3-Dichloropropene

1,2-Dimethylhydrazine

Hydrazine

Isoprene

Isopropanol

Malonaldehyde (malondialdehyde)

4,4'-Methylenediphenyl diisocyanate and polymeric 4,4'-Methylenediphenyl diisocyanate

Methyl methanesulfonate

2-Nitropropane

1,3-Propane sultone

β-Propiolactone

Resorcinol

1,1,1,2-Tetrachloroethane

Tetrafluoroethylene

1,1,2-Trichloroethane

Vinylidene chloride

N-Vinyl-2-pyrrolidone and polyvinyl pyrrolidone

Xylenes

 

Part Three B: Few new data

Acetamide

Acrylic acid

Allyl chloride

Allyl isovalerate

1,4-Benzoquinone (para-quinone)

1,4-Benzoquinone dioxime

Benzyl acetate

Bis(2-chloroethyl)ether

1,2-Bis(chloromethoxy)ethane

1,4-Bis(chloromethoxymethyl)benzene

Bis(2-chloro-1-methylethyl)ether

Bis(2,3-epoxycyclopentyl)ether

Bisphenol A diglycidyl ether

Bromochloroacetonitrile

Bromodichloromethane

Bromoethane

Bromoform

β-Butyrolactone

Carbazole

Chloroacetonitrile

Chlorodibromomethane

Chlorodifluoromethane

Chloroethane

Chlorofluoromethane

2-Chloro-1,1,1-trifluoroethane

Cyclohexanone

Decabromodiphenyl oxide

Dibromoacetonitrile

Dichloroacetonitrile

Dichloroacetylene

trans-1,4-Dichlorobutene

1,2-Dichloropropane

1,2-Diethylhydrazine

Diethyl sulfate

Diglycidyl resorcinol ether

Diisopropyl sulfate

1,1-Dimethylhydrazine

Dimethyl hydrogen phosphite

3,4-Epoxy-6-methylcyclohexylmethyl 3,4-epoxy-6-methyl-cyclohexane carboxylate

cis-9,10-Epoxystearic acid

Ethyl acrylate

Glycidaldehyde

Hexamethylphosphoramide

Isopropyl oils

Lauroyl peroxide

Methyl acrylate

2-Methylaziridine (propyleneimine)

Methyl iodide

Morpholine

1,5-Naphthalene diisocyanate

Pentachloroethane

Phenyl glycidyl ether

Tetrakis(hydroxymethyl)phosphonium salts

Trichloroacetonitrile

Triethylene glycol diglycidyl ether

Tris(2-chloroethyl) phosphate

1,2,3-Tris(chloromethoxy)propane

Vinylidene fluoride