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Some Industrial Chemicals

IARC Monographs on the Evaluation of Carcinogenic Risks to Humans Volume 77

IARC

ISBN-13 (Print Book)

978-92-832-1277-5

ISBN-13 (PDF)

978-92-832-1577-6

Formats

Print Book

PDF

Other languages

No other languages


Evaluates or re-evaluates the carcinogenic risks to humans posed by exposure to sixteen organic industrial chemicals. These included some aromatic amines (ortho-toluidine, 4-chloro-ortho-toluidine, and 5-chloro-ortho-toluidine), some ethanolamines (di- and triethanolamine and N-nitrosodiethanolamine), and three esters [di(2-ethylhexyl) phthalate (DEHP), di(2-ethylhexyl) adipate, and cinnamyl anthranilate]. Seven of the sixteen compounds were evaluated in previous IARC Monographs and are reconsidered here in the light of new evidence. Three chemicals were classified or reclassified as probably carcinogenic to humans: ortho-toluidine, 4-chloro-ortho-toluidine, and glycidol. Four compounds, evaluated here for the first time, namely 2,2-bis(bromomethyl)propane-1,3-diol, 2,3-dibromopropan-1-ol, ethylbenzene, and nitromethane, were classified as possibly carcinogenic to humans. N-Nitrosodiethanolamine, which can readily be formed from either di- or triethanolamine in the presence of inorganic nitrite, remained classified as possibly carcinogenic to humans. For eight compounds, including 5-chloro-ortho-toluidine, coumarin, pyridine, diethanolamine, triethanolamine, di(2-ethylhexyl) adipate, and cinnamyl anthranilate, evidence was judged inadequate to classify these compounds according to their carcinogenicity in humans. The most extensive monograph is devoted to an evaluation of di(2-ethylhexyl) phthalate (DEHP), which had previously been classified as possibly carcinogenic to humans. Using assessment criteria recently established for compounds that induce peroxisome proliferation in the liver, the evaluation downgraded DEHP to the group of compounds that cannot be classified. Two other compounds that cause peroxisome proliferation, di(2-ethylhexyl) adipate and cinnamyl anthranilate, were also evaluated as not classifiable as to carcinogenicity to humans.

PLEASE NOTE: Some commercial firms have cited this volume while making erroneous claims that IARC has classified DEHP as non-carcinogenic. These claims are false. The findings in this volume are not a determination of non-carcinogenicity or overall safety.

 

FRONT AND BACK MATTER

  Cover
  Contents and Note to the Reader
  List of Participants
  Preamble
  General Remarks
  Summary of Final Evaluations
  Cumulative Cross Index to IARC Monographs

 

 

THE MONOGRAPHS

 

Di(2-ethylhexyl) phthalate

Di(2-ethylhexyl) adipate

Cinnamyl anthranilate

Coumarin

Ethylbenzene

ortho-Toluidine [superseded by Volume 99]

4-Chloro-ortho-toluidine [superseded by Volume 99]

5-Chloro-ortho-toluidine

Diethanolamine

Triethanolamine

N-Nitrosodiethanolamine

2,3-Dibromopropan-1-ol

2,2-Bis(bromomethyl)propane-1,3-diol

Glycidol

Nitromethane

Pyridine