Colposcopy and Treatment of Cervical Precancer

IARC Technical Publication No. 45

Authors: Walter Prendiville and Rengaswamy Sankaranarayanan






Other languages

No other languages

This colposcopy manual was developed in the context of the cervical cancer screening research studies of the International Agency for Research on Cancer (IARC) and the related technical support provided to national programmes. It is thus a highly comprehensive manual, both for the training of new colposcopists and for the continuing education and reorientation of those who are more experienced. This manual offers a valuable learning resource, incorporating recent developments in the understanding of the etiology and pathogenesis of cervical intraepithelial neoplasia (CIN), as well as in colposcopy and cervical pathology.

Expertise in performing satisfactory, safe, and accurate colposcopic examinations requires high competence in the technical, interpretive, and cognitive aspects, and the capability to develop pragmatic and effective management plans and treatment. This comprehensive and concise manual covers all these aspects and serves as a useful handbook for acquiring the necessary skills for the visual recognition and interpretation of colposcopic findings and for developing the personal and professional attributes required for competence in colposcopy.

Cover pages


Table of Contents





Chapter 1. The role of colposcopy in cervical precancer

Chapter 2. Anatomy of the uterine cervix and the transformation zone

Chapter 3. Squamous intraepithelial lesions: cytology–histology correlation

Chapter 4. The effect of oncogenic HPV on transformation zone epithelium

Chapter 5. Equipment for a colposcopic examination

Chapter 6. A systematic approach to colposcopic examination

Chapter 7. Colposcopic terminology: the 2011 IFCPC nomenclature

Chapter 8. Colposcopic appearance of the normal cervix

Chapter 9. Inflammatory lesions of the cervix

Chapter 10. Colposcopic examination of the abnormal cervix

Chapter 11. Treatment of cervical intraepithelial neoplasia (CIN)

Chapter 12. Glandular abnormalities, adenocarcinoma in situ, and glandular intraepithelial neoplasia

Chapter 13. Microinvasive squamous cervical cancer

Chapter 14. Surgical management of early invasive cervical cancer

Chapter 15. Non-surgical management of cervical cancer

Chapter 16. Follow-up after treatment of cervical intraepithelial neoplasia (CIN)

Chapter 17. Pregnancy, contraception, menopause, and hysterectomy

Chapter 18. Quality assurance: fail-safe protocols and clean equipment


Annex 1. Transformation zone types

Annex 2. Standard form for documenting the examination findings

Annex 3. 2011 IFCPC colposcopic terminology of the cervix

Annex 4. The Swede score

Annex 5. Preparation of 5% acetic acid, Lugol’s iodine solution, and Monsel’s paste

Disclosures of interests



Back cover